Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    A Novel Compound Lup‑20 (29)‑ene‑3α,6β‑diol Identified in Petroleum Ether Extract of Diospyros melanoxylon Roxb. Leaves and to Reveal Its Antidiabetic Activity in Rats

    Anil Kumar Sharma1★, Tek Chand Sharma2, Ruchi Singh2,3, Pratibha Payal2, Rajnish Gupta4,5, Mahesh Chandra Sharma2★ Corresponding author

    1. 1Department of Chemistry, Jagan Nath University.
    2. 2Department of Chemistry, Natural Products Laboratory, University of Rajasthan.
    3. 3Department of Chemistry, The IIS University.
    4. 4Department of Zoology, University of Rajasthan, Jaipur, Rajasthan.
    5. 5Department of Neurobehavioral Toxicology, ICMR‑NIOH, Ahmedabad, Gujarat, University, India.

    CORRESPONDENCE

    Anil Kumar Sharma

    Department of Chemistry, Jagan Nath University.

    anilkumarsharma_008@yahoo.com

    Received: 17-09-2017; Revised: 30-10-2017.

    Volume 14, Issue 55s · pp. S245–S248 · PUBLISHED 28 June 2018 · DOI: 10.4103/pm.pm_429_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Diospyros melanoxylon Roxb. belongs to the family Ebenaceae and its leaves show diuretic, carminative, laxative, and styptic bioactivities. Objective: The objective of this study was to give a direction for future investigators to carry out research on phytochemistry and develop a potent antidiabetic agent. Materials and Methods: Petroleum ether extract of D. melanoxylon Roxb. leaves was chromatographed over silica gel column. Isolated compounds were elucidated on the basis of different spectroscopic techniques (mass spectrometry, infrared, 1H, 13C nuclear magnetic resonance, and distortionless enhancement by polarization transfer). Antidiabetic activity of lup‑20 (29)‑ene‑3,6 β‑diol was evaluated in streptozotocin diabetic rats. Results: A novel compound, lup‑20 (29)‑ene‑3,6 β‑diol (6), was identified along with 11 known natural compounds, namely, lupeol (1), ceryl alcohol (2), octacosanol‑1 (3), hentriacontanol‑1 (4), β‑sitosterol (5), diospyrin (7), 3‑methoxydiospyrin (8), betulin (9), ursolic acid (10), betulinic acid (11), and oleanolic acid (12). Further administration of lup‑20 (29)‑ene‑3,6 β‑diol significantly improved the diabetes‑induced oxidative stress. Conclusion: Investigation of this novel compound plays an important role in the field of drug development.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Sharma, A. K., Sharma, T. C., Singh, R., Payal, P., Gupta, R., & Sharma, M. C. (2018). A Novel Compound Lup‑20 (29)‑ene‑3α,6β‑diol Identified in Petroleum Ether Extract of Diospyros melanoxylon Roxb. Leaves and to Reveal Its Antidiabetic Activity in Rats. Pharmacognosy Magazine, 14(55s), S245–S248. https://doi.org/10.4103/pm.pm_429_17