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    Pharmacognosy MagazineNOW IN
    Article

    Dendrobium officinale Kimura et Migo Improved Dry Eye Symptoms via Promoting Tear Production in an Experimental Dry Eye Rat Model

    Qiang Zeng2,3,4, Wing‑Sum Siu2,3, Chun‑Hay Ko2,3, Chun‑Wai Wong2,3, Clara Bik‑San Lau2,3, Zheng‑Zhi Wu4★, Jiang‑Miao Hu5★, Ping‑Chung Leung2,3★★ Corresponding author

    1. 1Institute of Chinese Medicine, The Chinese University of Hong Kong, China.
    2. 2State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
    3. 3Shenzhen Institute of Geriatrics, The First Affiliated Hospital of Shenzhen University (Shenzhen Second People’s Hospital), Shenzhen, Guangdong, China.
    4. 4State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China.

    CORRESPONDENCE

    Zheng‑Zhi Wu

    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China.

    szwzz001@email.szu.edu.cn

    Received: 30-09-2019; Revised: 11-11-2019; Accepted: 17-02-2020.

    Volume 16, Issue 69 · pp. 294–302 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_435_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is the most studied species, but other species like <em>Cissus vitiginea</em> L. also possess pharmacological potential. Objective: To evaluate the antioxidant, anti-inflammatory, and anti-arthritic activities of the methanolic extract of <em>Cissus vitiginea</em> (MECV) leaves. Materials and Methods: The antioxidant activity was assessed using DPPH, hydroxyl radical, and superoxide radical scavenging assays. The anti-inflammatory activity was evaluated using the carrageenan-induced rat paw edema model. The anti-arthritic activity was assessed using the adjuvant-induced arthritis model in rats. Results: MECV showed significant antioxidant activity in a dose-dependent manner. In the carrageenan-induced paw edema model, MECV (200 and 400 mg/kg) significantly reduced paw edema. In the adjuvant-induced arthritis model, MECV treatment significantly reduced the paw volume and improved the hematological parameters compared to the arthritic control group. Conclusion: The results suggest that <em>Cissus vitiginea</em> possesses significant antioxidant, anti-inflammatory, and anti-arthritic activities, which could be attributed to the presence of phytochemicals like flavonoids and phenolic compounds.

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      Zeng, Q., Siu, W., Ko, C., Wong, C., Lau, C. B., Wu, Z., Hu, J., & Leung, P. (2020). Dendrobium officinale Kimura et Migo Improved Dry Eye Symptoms via Promoting Tear Production in an Experimental Dry Eye Rat Model. Pharmacognosy Magazine, 16(69), 294–302. https://doi.org/10.4103/pm.pm_435_19