D‑Carvone Attenuates Biochemical and Molecular Expression via Oncogenic Signaling in Aryl Hydrocarbon‑Induced Hamster Mucosal Carcinogenesis
Jingxuan Wang1, Yan Hu2, Yifan Wang2, Yingshun Yang2, Song Li2, Yujiao Hou2, Zhizheng Zhuang2★, Fan Wu2★ Corresponding author
- 1Department of Stomatology, Baoding First Central Hospital, China.
- 2Department of Stomatology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
CORRESPONDENCE
Zhizheng Zhuang
Department of Stomatology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Received: 19-07-2019; Revised: 27-08-2019; Accepted: 18-10-2019.
Volume 16, Issue 69 · pp. 303–310 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_302_19
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ABSTRACT
Background: Chemo prevention through nutritional constituents has appeared as an innovative methodology to control the oral cancer incidence. The main target of this research exists to explore the chemopreventive effect of D‑carvone by way of biochemical and molecular prototype during 7,12‑dimethylbenz[a] anthracene (DMBA)‑stimulated hamsters mucosal carcinogenesis. Materials and Methods: Topical application of 0.5% DMBA in liquid paraffin, thrice a week, for 10 weeks well developed oral squamous cell carcinoma in hamsters cheek pouch (HCP). All the same 100% tumor formation was perceived in hamsters induced with DMBA alone, but intragastric administration of D‑carvone, at a dose of 10 mg/kg bw, to DMBA‑treated hamster totally prevented the formation of oral tumor. Results: D‑carvone significantly lessens lipid peroxidation (LPO) by‑products and enhanced the status of enzymatic, non-enzymatic antioxidants, and varied the status of Phase I and II xenobiotic enzymes, favoring the secretion of cancer metabolites through downregulation of proliferating cell nuclear antigen and p53 expression during oral tumor hamsters. Conclusion: The nearby study suggests that D‑carvone relies on its anti‑LPO, antioxidant, xenobiotic metabolic enzymes as well as anti‑cell proliferation and induced apoptosis during DMBA‑induced hamster oral mucosal carcinogenesis.
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Wang, J., Hu, Y., Wang, Y., Yang, Y., Li, S., Hou, Y., Zhuang, Z., & Wu, F. (2020). D‑Carvone Attenuates Biochemical and Molecular Expression via Oncogenic Signaling in Aryl Hydrocarbon‑Induced Hamster Mucosal Carcinogenesis. Pharmacognosy Magazine, 16(69), 303–310. https://doi.org/10.4103/pm.pm_302_19