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    Antitumoral Effect of Lawsonia inermis Extract on Melanoma Tumor‑bearing C57BL/6 Mice

    Wasim Raja2,3★, Sonam Pandey2,4★ Corresponding author

    1. 1Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, Madhya Pradesh, 2 Department of Central Laboratory Facility, Central Laboratory Facility, Chhattisgarh Council of Science and Technology, Raipur, Chhattisgarh, 3 Gujarat State Biotechnology Mission, Gandhinagar, Gujarat, India ORIGINAL ARTICLE.

    CORRESPONDENCE

    Wasim Raja

    spdhanabal@jssuni.edu.in

    Received: 21-05-2019; Revised: 01-07-2019; Accepted: 12-03-2020.

    Volume 16, Issue 70S · pp. S435–S442 · PUBLISHED 20 May 2020 · DOI: 10.4103/pm.pm_219_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>. Materials and Methods: The antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and total antioxidant capacity assays. The anti-inflammatory activity was evaluated using the protein denaturation inhibition assay and the membrane stabilization assay. Results: The methanolic extract of <em>C. arnottiana</em> showed significant antioxidant activity in all the assays. It also exhibited potent anti-inflammatory activity by inhibiting protein denaturation and stabilizing the red blood cell membrane. Conclusion: The results suggest that <em>C. arnottiana</em> has significant antioxidant and anti-inflammatory potential, which could be attributed to the presence of phytochemicals like flavonoids and phenolic compounds.

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      Raja, W., & Pandey, S. (2020). Antitumoral Effect of Lawsonia inermis Extract on Melanoma Tumor‑bearing C57BL/6 Mice. Pharmacognosy Magazine, 16(70S), S435–S442. https://doi.org/10.4103/pm.pm_219_19