Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Activity of Parotid Exudate of Bufo melanostictus
Allenki Venkatesham1, Neerati Prasad1, Devarakonda R Krishna1, Yellu Narsimha Reddy1★★ Corresponding author
- 1Pharmacology and Clinical Pharmacy Division, University College of Pharmaceutical Sciences, Kakatiya University, Warangal – 506 009, Andhra Pradesh, INDIA.
Received: 23-12-2009; Accepted: 08-02-2009.
Volume 1, Issue 2 · pp. 98–101 · PUBLISHED Mar-Apr 2009 · DOI:
View on Pharmacogn. Res. original site ↗
ABSTRACT
Type 2 diabetes arises as a result of β-cell failure combined with concomitant insulin resistance. Glucagon-like peptide-1 is a gastrointestinal hormone that is released postprandially from the L cells of the gut and exerts a glucose- dependent and direct insulinotropic effect on the pancreatic β cell. Which activate adenylate cyclase and enhances insulin secretion. GLP-1 is rapidly degraded by DPP-IV to GLP-1(9-37) amide following release from gut L cells. GLP-1 directly enhances glucose-dependent insulin secretion via an increase in β-cell cAMP. Dipeptidyl peptidase IV (DPP-IV) is a plasma membrane glycoprotein ectopeptidase. In mammals, DPP-IV was widely expressed on the surface of endothelial and epithelial cells and highest levels in humans have been reported to occur in the intestine, bone marrow and kidney. Inhibiting DPP-IV reduces its rapid degradation of GLP-1, increasing circulating levels of the active hormone in vivo and prolonging its beneficial effects. The IC50 value of parotid exudate was found to be 9.4 µg/ml. The maximum % inhibition (61.8) was showed at a concentration of 12µg/ml. Parotid exudate through inhibition of DPP-IV, improves glucose tolerance and enhances insulin secretion. DPP-IV inhibitors are a novel class of oral hypoglycemic agents with a potential to improve pancreatic beta cell function and the clinical course of type 2 diabetes.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Venkatesham, A., Prasad, N., Krishna, D. R., & Reddy, Y. N. (2009). Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Activity of Parotid Exudate of Bufo melanostictus. Pharmacognosy Research, 1(2), 98–101.