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    Article

    Identification, Preliminary Genetic, and Biochemical Analyses the Hedera Plants Which Naturally Distribute in Vietn

    Nguyen Tuan Hiep1, Pham Thi Hong Nhung2, Nguyen Hoai Nguyen3, Do Thi Thuy Linh1, Hoang Thanh Duong1, Do Thi Le Hang2, Pham Thanh Huyen1, Vu Thi Thom2, Nguyen Minh Khoi1, Dinh Doan Long2★★ Corresponding author

    1. 1Department of Extraction Technology and Department of Medicinal Resources, National Institute of Medicinal Materials, Hanoi, VIETNAM.
    2. 2Department of Basic Sciences in Medicine and Pharmacy, VNUH-University of Medicine and Pharmacy, Hanoi, VIETNAM.
    3. 3Department of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, VIETNAM.

    CORRESPONDENCE

    Dinh Doan Long

    Department of Basic Sciences in Medicine and Pharmacy, VNUH-University of Medicine and Pharmacy, Hanoi, VIETNAM.

    dinhdoanlong.smp@gmail.com

    Received: 07-07-2020; Revised: 03-09-2020; Accepted: 18-09-2020.

    Volume 12, Issue 4 · pp. 450–454 · PUBLISHED · DOI: 10.4103/pr.pr_65_20

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Hedera is a genus of 12–15 species of evergreen climbing woody plants in the family Araliaceae that are considered as traditional medicinal plants. Objectives:The objectives were to classify Hedera species collected from different areas in Vietnam and characterize some chemical compounds of these species. Materials and Methods: In this study, the DNA-based technique was used to classify and analyze the genetic source of 21 Hederaplant samples found in Vietnam. In addition, high-performance liquid chromatography (HPLC) is also employed to assess the chemical compounds of these plants. Results: The collected plants mainly distribute into three groups (named as N1, N2, and N3). Based on the phenotypic identification and genetic analysis, the N1 group is indicated as Hedera nepalensis (H. nepalensis), while N3 is Hedera helix (H. helix). The HPLC analysis indicates that most of them contained more hederacoside C than α-hederin. Moreover, N1 plants are able to produce hederacoside C as N3 even the accumulation levels in N1 are moderately lower than those in N3 plants. Conclusion: These results provide important information about the local Hedera plants and help us to select the good medicinal sources for further applications in biomedical sciences.

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      Hiep, N. T., Nhung, P. T. H., Nguyen, N. H., Linh, D. T. T., Duong, H. T., Hang, D. T. L., Huyen, P. T., Thom, V. T., Khoi, N. M., & Long, D. D. (). Identification, Preliminary Genetic, and Biochemical Analyses the Hedera Plants Which Naturally Distribute in Vietn. Pharmacognosy Research, 12(4), 450–454. https://doi.org/10.4103/pr.pr_65_20