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    Article

    Acute Toxicity and Cytogenotoxicity of Yangambin Isolated from Ocotea duckei Vattimo‑Gil

    Maria Isabel de Assis Lima Castro1★, Marta Gerusa Soares de Lucena2, Camilla Vila Nova Soares Silva3, Yhasminie Karine da Silva Xavie1, José Maria Barbosa Filho4, Maria Madalena Rocha Silva Teles4, Laisla Rangel Peixoto4, Ivone Antônia de Souza1, Eliete Cavalcanti da Silva2★ Corresponding author

    1. 1Postgraduate Program in Morphotechnology - Federal University of Pernambuco, João Pessoa, PB, BRAZIL.
    2. 2Postgraduate Program in Morphotechnology - Federal University of Pernambuco; Department of Histology and Embryology-Federal University of Pernambuco, João Pessoa, PB, BRAZIL.
    3. 3Multiprofessional Residency Program in Health Surveillance - Recife Health Department, João Pessoa, PB, BRAZIL.
    4. 4Institute of Drugs and Medicines Research - Federal University of Paraíba, 58051 900, João Pessoa, PB, BRAZIL.

    CORRESPONDENCE

    Maria Isabel de Assis Lima Castro

    Postgraduate Program in Morphotechnology - Federal University of Pernambuco, João Pessoa, PB, BRAZIL.

    isabellima878@gmail.com

    Received: 04-08-2020; Revised: 13-08-2020; Accepted: 18-09-2020.

    Volume 12, Issue 4 · pp. 444–449 · PUBLISHED · DOI: 10.4103/pr.pr_73_20

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Yangambin, a lignan isolated from Ocotea duckei leaves, has been reported to have antitumor, anxiolytic, hypotensive, and leishmanicidal activity, but there is little information on toxicity. Objective:The aim of this study was to investigate the acute toxicity of yangambin in mice, and cytotoxicity and genotoxicity through the Allium cepa assay. Materials and Methods: The yanganbin at a dose of 2000 mg/kg was orally administered once to mice to investigate acute toxicity, and meristem of the roots of Allium cepawas used to determine inhibition of root growth (root length) and mitotic index. Results: Yangambin did not cause hemolysis in sheep erythrocytes at concentrations of 12.5, 25, and 50 µg/mL, and did not show genotoxic changes in root meristem cells of Allium cepa at the same concentrations. In the acute toxicity study in Swiss mice at a dose of 2000 mg/kg, there were no apparent clinical signs or any behavioral changes and no deaths. Conclusion: Therefore, yangambin appears to a promising active compound for future pharmacological studies.

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      Castro, M. I. D. A. L., Lucena, M. G. S. D., Silva, C. V. N. S., Xavie, Y. K. D. S., Filho, J. M. B., Teles, M. M. R. S., Peixoto, L. R., Souza, I. A. D., & Silva, E. C. D. (). Acute Toxicity and Cytogenotoxicity of Yangambin Isolated from Ocotea duckei Vattimo‑Gil. Pharmacognosy Research, 12(4), 444–449. https://doi.org/10.4103/pr.pr_73_20