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    Aflatoxin: A Prevalent Toxin in the Demesne of Existence

    Aishik Banerjee1, Arup Ghosh1, Amartya Nandi1, Deyasini Saha1, Santosh Kumar Sahoo1, Amit Kundu1, Revu Baby Nalanda1, Naresh Panigrahi1, Partha Roy1, Sumanta Mondal1★★ Corresponding author

    1. 1Department of Pharmaceutical Chemistry, School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, INDIA.

    CORRESPONDENCE

    Sumanta Mondal

    Associate Professor and NSS Programme Officer (Unit-IX), Department of Pharmaceutical Chemistry, School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, INDIA.

    msumanta@gitam.edu

    Received: 27-02-2025; Revised: 09-04-2025; Accepted: 14-06-2025.

    Volume 17, Issue 3 · pp. 740–754 · PUBLISHED Jul-Sep 2025 · DOI: 10.5530/pres.20252183

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Aflatoxin, a mycotoxin origin from food-borne microbes, poses a significant and remarkable risk to the safety and integrity of food. Mycotoxin-producing fungi can infect goods intended for human and animal consumption, impacting both populations. Among mycotoxins, aflatoxin B1 harms many living organisms, including microorganisms, plants, laboratories, pet animals, and cultured cells. Aflatoxins are incredibly liposoluble and easily absorbed from the exposure site, typically entering the bloodstream through the respiratory and gastrointestinal systems. In humans and animals, the reactive form of aflatoxin, AFB1, is metabolized through cytochrome P450 microsomal enzymes into aflatoxins-8,9-epoxide, which then binds with DNA and albumins present in blood serum, forming an active-adducts that damage DNA. Aflatoxins are the well-researched class of mycotoxins, with clear correlations to carcinogenic, hepatotoxic, mutagenic, and teratogenic effects. Therefore, aflatoxin detection is crucial for maintaining food safety and public health, as mycotoxins can withstand high temperatures during storage and cooking. Several analytical and chemical methods can detect, identify, and control aflatoxin contamination with precision, contributing to food safety and public health. Further worldwide research is crucial to deepen our understanding of toxic pollutants, toxicity patterns, regulatory mechanisms, and decontamination strategies, as preventing aflatoxin contamination needs adequate funding and collaboration.

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      Banerjee, A., Ghosh, A., Nandi, A., Saha, D., Sahoo, S. K., Kundu, A., Nalanda, R. B., Panigrahi, N., Roy, P., & Mondal, S. (2025). Aflatoxin: A Prevalent Toxin in the Demesne of Existence. Pharmacognosy Research, 17(3), 740–754. https://doi.org/10.5530/pres.20252183