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    Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals

    S. A. Onasanwo1,2, Neetu Singh2, A. B. Saba3, A. A. Oyagbemi3★, O. A. Oridupa3, Gautam Palit2★ Corresponding author

    1. 1Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria
    2. 2Division of Pharmacology, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
    3. 3Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria

    CORRESPONDENCE

    A. A. Oyagbemi

    *Address for correspondence: Dr. A. A. Oyagbemi, Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria.

    ademolaoyagbemi@yahoo.com

    Revised: 07-11-2010.

    Volume 3, Issue 1 · pp. 2–8 · PUBLISHED January 2011 · DOI: 10.4103/0974-8490.79108

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB) whole fruit in laboratory rats. Methods The anti-ulcer property of the ethanolic extract of the whole fruit of Lagenaria breviflora (LB) was assessed using the cold-restraint stress-induced (CRU) gastric ulcer, pyloric ligation-induced (PL) gastric ulcer, aspirin-induced (ASP) gastric ulcer and alcohol-induced (AL) gastric ulcer models. The scavenging activity of the LB extract was examined with 1, 1-diphenyl-2-picryl-hydrazyl (DPPH), Nitric oxide, Hydroxyl radical and Superoxide anion scavenging models. Results EELB (50, 100, 150 and 200 mg/kg, b.w.) protected against the CRU gastric ulcer dose dependently. Similarly, 150 mg/kg b.w. of the LB extract protected against the PL gastric ulcer, ASP gastric ulcer and AL gastric ulcer and was comparable to omeprazole (10 mg/kg b.w.) or Suscralfate (500 mg/kg b.w.), respectively. The in vitro antioxidant activity of LB was demonstrated by its ability to quench free radicals generated by nitric oxide and superoxide anion with a concomitant scavenging potential against DPPH-induced radical formation. Conclusion Taken together, the study showed that the whole fruit extract possess potent anti-ulcer and antioxidant activities.

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      Onasanwo, S. A., Singh, N., Saba, A. B., Oyagbemi, A. A., Oridupa, O. A., & Palit, G. (2011). Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals. Pharmacognosy Research, 3(1), 2–8. https://doi.org/10.4103/0974-8490.79108