Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    The study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats

    H. Kirana1★, M. V. Jali1, B. P. Srinivasan2★ Corresponding author

    1. 1T.V.M. College of Pharmacy, Gandhi Nagar, Bellary-583 103
    2. 2Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Sector-III, Pushp Vihar, New Delhi-110 017, India

    CORRESPONDENCE

    H. Kirana

    *Address for correspondence: Dr. Kirana Halagappa, TVM College of Pharmacy, Gandhi Nagar, Bellary-583 103, India.

    bpsrinivasan@yahoo.com

    Revised: 22-10-2010.

    Volume 3, Issue 1 · pp. 30–34 · PUBLISHED January 2011 · DOI: 10.4103/0974-8490.79112

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Chronic systemic inflammation is an early process in pathogenesis of type 2 diabetes. Hence the present study was aimed to investigate the effect of traditionally known plant Ficus religiosa on elevated glucose and inflammatory marker namely tumor necrosis factor (TNF)-α in type 2 diabetic rats. Methods Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rat model. Aqueous extract of F. religiosa at a dose of 100 and 200 mg/ kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose and TNF-α in serum were analyzed. Results Aqueous extract of F. religiosa at both dose levels i.e., 100 and 200 mg/kg decreased the elevated glucose and TNF-α in type 2 diabetic rats. The extract at 200 mg/kg had more pronounced effect. Conclusion Modulation of cytokine TNF-α by the aqueous extract of F. religiosa indicates that the anti-inflammatory and immunomodulatory property of the plant is related with its potential anti-diabetic activity.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Kirana, H., Jali, M. V., & Srinivasan, B. P. (2011). The study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats. Pharmacognosy Research, 3(1), 30–34. https://doi.org/10.4103/0974-8490.79112