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    Article

    Colon-targeted quercetin delivery using natural polymer to enhance its bioavailability

    Anil Singhal1★, H. Jain1, Vipin Singhal3, Edwin J. Elias2, Ahmad Showkat2★ Corresponding author

    1. 1B. R. Nahata College of Pharmacy, BRNSS-Contract Research Center, Mhow-Neemuch Road, Mandsaur, Madhya Pradesh
    2. 2Unijules Life Science Ltd. and Associated Companies, Nagpur
    3. 3Seth G L Bihani College of Technical Education, Sri Ganganagar, India

    CORRESPONDENCE

    Anil Singhal

    *Address for correspondence: Anil Kumar Singhal, B. R. Nahata College of Pharmacy, Mhow Neemuch Road, Mandsaur (M. P.) 458001, India

    anil_singhal20@yahoomail.com

    Revised: 15-06-2010.

    Volume 3, Issue 1 · pp. 35–39 · PUBLISHED January 2011 · DOI: 10.4103/0974-8490.79113

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    The aim of the present study is to develop a polymer (Guar Gum)-based matrix tablet (using quercetin as a model drug) with sufficient mechanical strength, and promising in vitro mouth-to- colon release profile. By definition, an oral colonic delivery system should retard drug release in the stomach and small intestine, and allow complete release in the colon. By drug delivery to the colon would therefore ensure direct treatment at the disease site, lower dosing, and fewer systemic side effects. Quercetin is antioxidant in nature and used to treat colon cancer, but they have poor absorption in the upper part of the gastrointestinal tract (GIT). As a site for drug delivery, the colon offers a near neutral pH, reduced digestive enzymatic activity, a long transit time, and an increased responsiveness to absorption enhancers. By achieving a colon-targeted drug delivery system, the absorption of quercetin may be increased, which leads to better bioactivity in fewer doses.

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      Singhal, A., Jain, H., Singhal, V., Elias, E. J., & Showkat, A. (2011). Colon-targeted quercetin delivery using natural polymer to enhance its bioavailability. Pharmacognosy Research, 3(1), 35–39. https://doi.org/10.4103/0974-8490.79113