Volume 3, Issue 1

Prophylactic measures

Ambrose Furey

pp. 1–1 · DOI: 10.4103/0974-8490.79107 · Published January 2011

Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals

S. A. Onasanwo, Neetu Singh, A. B. Saba, A. A. Oyagbemi, O. A. Oridupa, Gautam Palit

pp. 2–8 · DOI: 10.4103/0974-8490.79108 · Published January 2011

Background The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB) whole fruit in laboratory rats. Methods The anti-ulcer property of t…

In vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines

H. M. Suresh, B. Shivakumar, K. Hemalatha, S. S. Heroor, D. S. Hugar, K. R. S. Sambasiva Rao

pp. 9–12 · DOI: 10.4103/0974-8490.79109 · Published January 2011

Background The phytochemical and pharmacological activities of Annona reticulata components suggest a wide range of clinical application in lieu of cancer chemotherapy. Materials and Methods Ethanol and aqueous extracts …

Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats

Kingshuk Lahon, Swarnamoni Das

pp. 13–18 · DOI: 10.4103/0974-8490.79110 · Published January 2011

Background There is a lack of reliable hepatoprotective drugs in modern medicine to prevent and treat drug-induced liver damage. Leaves of Sacred/Holy Basil, i.e. Green Tulsi (Ocimum sanctum), belonging to family Lamiace…

Mining of simple sequence repeats in the Genome of Gentianaceae

R. Sathishkumar, P. T. V. Lakshmi, A. Annamalai, V. Arunachalam

pp. 19–29 · DOI: 10.4103/0974-8490.79111 · Published January 2011

Simple sequence repeats (SSRs) or short tandem repeats are short repeat motifs that show high level of length polymorphism due to insertion or deletion mutations of one or more repeat types. Here, we present the detectio…

The study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats

H. Kirana, M. V. Jali, B. P. Srinivasan

pp. 30–34 · DOI: 10.4103/0974-8490.79112 · Published January 2011

Background Chronic systemic inflammation is an early process in pathogenesis of type 2 diabetes. Hence the present study was aimed to investigate the effect of traditionally known plant Ficus religiosa on elevated glucos…

Colon-targeted quercetin delivery using natural polymer to enhance its bioavailability

Anil Singhal, H. Jain, Vipin Singhal, Edwin J. Elias, Ahmad Showkat

pp. 35–39 · DOI: 10.4103/0974-8490.79113 · Published January 2011

The aim of the present study is to develop a polymer (Guar Gum)-based matrix tablet (using quercetin as a model drug) with sufficient mechanical strength, and promising in vitro mouth-to- colon release profile. By defini…

Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves

P. Suresh Babu, V. Krishna, K. R. Maruthi, K. Shankarmurthy, Ramesh K. Babu

pp. 40–43 · DOI: 10.4103/0974-8490.79114 · Published January 2011

Background D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye d…

Partial in vitro and in vivo red scorpion venom neutralization activity of Andrographis paniculata

Ranjana I. Brahmane, Swanand S. Pathak, Vikrant V. Wanmali, Kartik J. Salwe, S. John Premendran, Bhawna B. Shinde

pp. 44–48 · DOI: 10.4103/0974-8490.79115 · Published January 2011

Objective Red scorpion (Mesobuthus tamulus) is the most lethal among all poisonous species of scorpions. Envenoming by Mesobuthus tamulus is quite common along the western coast of India, without any established therapy.…

Standardization of some herbal antidiabetic drugs in polyherbal formulation

Harinarayan Singh Chandel, A. K. Pathak, Mukul Tailang

pp. 49–56 · DOI: 10.4103/0974-8490.79116 · Published January 2011

Background Ayurvedic formulations are used to treat a wide variety of diseases including diabetes mellitus Standardization of herbal formulation is essential in order to assess the quality of drugs. The present paper rep…

Analgesic activity and acute toxicity study of Semecarpus anacardium stem bark extracts using mice

G. M. Lingaraju, H. Joy Hoskeri, V. Krishna, P. Suresh Babu

pp. 57–61 · DOI: 10.4103/0974-8490.79117 · Published January 2011

Background The analgesic activity of petroleum ether, chloroform and methanol extracts of Semecarpus anacardium was investigated by tail flicking and writhing method using acetyl salicylic acid as the standard reference.…

Effect of methanolic extract of Lagenaria siceraria (Molina) Standley fruits on marble-burying behavior in mice: Implications for obsessive–compulsive disorder

R. P. Prajapati, M. V. Kalaria, V. P. Karkare, S. K. Parmar, N. R. Sheth

pp. 62–66 · DOI: 10.4103/0974-8490.79118 · Published January 2011

Context Obsessive–compulsive disorder (OCD) is the fourth most common mental disorder and is diagnosed nearly as often as asthma and diabetes mellitus. Over the last decade, the inhibition of burying of glass marbles by …

Antihyperglycemic effect of the alcoholic seed extract of Swietenia macrophylla on streptozotocin-diabetic rats

Kalpana Kalaivanan, Kodukkur Viswanathan Pugalendi

pp. 67–71 · DOI: 10.4103/0974-8490.79119 · Published January 2011

Background Streptozotocin (STZ) selectively destroys the pancreatic insulin secreting cells, leaving less active cells and resulting in a diabetic state. The present study was designed to investigate the antihyperglycemi…

Biomedical Research from Ideation to Publication

Arun H. S. Kumar

pp. 72–78 · DOI: · Published January 2011