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    In vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines

    H. M. Suresh1★, B. Shivakumar2, K. Hemalatha3, S. S. Heroor1, D. S. Hugar1, K. R. S. Sambasiva Rao4★ Corresponding author

    1. 1Department of Pharmacognosy, H.K.E. Society’s College of Pharmacy, Gulbarga, Karnataka
    2. 2Department of Pharmaceutical Chemistry, B.L.D.E.A.’s College of Pharmacy, Bijapur, Karnataka
    3. 3Department of Pharmaceutical Chemistry, Mallareddy College of Pharmaceutical Sciences, Hyderabad
    4. 4Department of Biotechnology, Acharya Nagarjuna University, Guntur, AP, India

    CORRESPONDENCE

    H. M. Suresh

    *Address for correspondence: H. M. Suresh, Department of Pharmacognosy, H.K.E. Society’s College of Pharmacy, Sedam Road, Gulbarga, Karnataka, India.

    srsh_hm@rediffmail.com

    Revised: 09-10-2010.

    Volume 3, Issue 1 · pp. 9–12 · PUBLISHED January 2011 · DOI: 10.4103/0974-8490.79109

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background The phytochemical and pharmacological activities of Annona reticulata components suggest a wide range of clinical application in lieu of cancer chemotherapy. Materials and Methods Ethanol and aqueous extracts of roots of Annona reticulata Linn were studied for their in vitro antiproliferative activity on A-549 (human lung carcinoma), K-562 (human chronic myelogenous leukemia bone marrow), HeLa (human cervix) and MDA-MB (human adenocarcinoma mammary gland) cancer cell lines by MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] colorimetric assay. Results The ethanol extract exhibited a prominent inhibitory effect against A-549, K-562, HeLa and MDA-MB human cancer cell lines at a concentration range between 10 and 40 μg/ml, whereas the aqueous extract showed a lower activity at the same concentration. Simultaneously, the effect of the ethanol extract toward the inhibition of Vero cell line proliferation was lower in comparison with the cancer cell lines. Conclusion The significant antiproliferative activity of the ethanol extract of Annona reticulata roots against A-549, K-562, HeLa and MDA-MB human cancer cell lines may be attributed toward the collective presence of acetogenins, alkaloids and lower inhibitory effect on Vero cell line, which suggests Annona reticulata be used as a chemopreventive agent in cancer therapy.

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      Suresh, H. M., Shivakumar, B., Hemalatha, K., Heroor, S. S., Hugar, D. S., & Rao, K. R. S. S. (2011). In vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines. Pharmacognosy Research, 3(1), 9–12. https://doi.org/10.4103/0974-8490.79109