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    Margaritaria discoidea (Euphorbiaceae) stem bark extract attenuates allergy and Freund’s adjuvant-induced arthritis in rodents

    David D. Obiri1★, Newman Osafo1, Joshua Oppong-Sarfo1, Jude K. Prah1★ Corresponding author

    1. 1Department of Pharmacology, Faculty of Pharmacy and Pharm. Sciences, College of Health Sciences, KNUST, Kumasi, Ghana

    CORRESPONDENCE

    David D. Obiri

    *Address for correspondence: Dr. D.D. Obiri, Department of Pharmacology, Kwame Nkrumah University of Science and Technology, Kumasi, Republic of Ghana.

    ddobiri.pharm@knust.edu.gh

    Revised: 02-08-2013.

    Volume 6, Issue 2 · pp. 163–171 · PUBLISHED April-June 2014 · DOI: 10.4103/0974‑8490.129039

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Various parts of Margaritaria discoidea find use in traditional medicine in the treatment of pain and oedema. This study evaluated the anti-allergic, anti-inflammatory and anti-arthritic effects of a 70% (v/v) aqueous ethanol extract of the stem bark of Margaritaria discoidea, MDE in rodents. Materials and Methods Systemic anaphylaxis was induced by the injection of compound 48/80 into mice and their survival rate was monitored to evaluate the anti-allergic action of the extract. The effect of MDE assessed on the maximal and total oedema responses in the mouse carrageenan–induced paw oedema was used to evaluate the anti-inflammatory action of the extract while the Freund’s adjuvant-induced arthritis model was employed to study the anti-arthritic effects of MDE. Results MDE dose-dependently increased the time for compound 48/80-induced mortality in mice. MDE suppressed the mean maximal swelling and the total paw swellings induced over 6 h in the carrageenan-induced paw oedema when administered either prophylactically or therapeutically. MDE caused a reduction in serum levels of TNFa and IL-6 and significantly suppressed Freund’s adjuvant-induced arthritis. Conclusion Margaritaria discoidea suppresses allergy and exhibits anti-inflammatory activity in mice. In addition it attenuates Freund’s adjuvant-induced arthritis through a reduction in serum levels of TNFa and IL-6 in rats.

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      Obiri, D. D., Osafo, N., Oppong-Sarfo, J., & Prah, J. K. (2014). Margaritaria discoidea (Euphorbiaceae) stem bark extract attenuates allergy and Freund’s adjuvant-induced arthritis in rodents. Pharmacognosy Research, 6(2), 163–171. https://doi.org/10.4103/0974‑8490.129039