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    Antihyperlipidemic potential of Albizia amara (Roxb) Boiv. bark against Triton X-100 induced hyperlipidemic condition in rats

    Rohit Gundamaraju1★, Kim Kah Hwi1, Rajeev K. Singla2, Ravi Chandra Vemuri1, Sartaj Banu Mulapalli3★ Corresponding author

    1. 1Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    2. 2Division of Biotechnology, Netaji Subhas Institute of Technology, Azad Hind Fauz Marg, Dwarka, New Delhi
    3. 3Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Dhulapally, Secunderabad, Andhra Pradesh, India

    CORRESPONDENCE

    Rohit Gundamaraju

    *Address for correspondence: Mr. Rohit Gundamaraju, Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

    rohit.gundamaraju@gmail.com

    Revised: 26-04-2014.

    Volume 6, Issue 4 · pp. 267–273 · PUBLISHED October-December 2014 · DOI: 10.4103/0974-8490.138237

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background The plant Albizia amara (Roxb.) Boiv. bark was used in traditional medical practices of India to treat cardiovascular diseases. Hyperlipidemia is the greatest risk factor of coronary heart disease. Objective The objective of this study was to screen the potential of A. amara against the condition of hyperlipidemia in rats. Materials and Methods The antihyperlipidemic activity of A. amara ethanolic extract (AAEE) was studied on Triton X-100 induced model of hyperlipidemia in rats. Hyperlipidemia in experimental rats was evidenced by an enhancement in the levels of serum cholesterol, triglycerides (TGs), low density lipoprotein (LDL), very LDL (VLDL) and decrease in high density lipoprotein (HDL). Results AAEE showed significant antihyperlipidemic effect by lowering the serum levels of biochemical parameters such as a significant reduction in the level of serum cholesterol, TG (104.1 ± 3.39), LDL (48.2 ± 2.19), VLDL (20.81 ± 0.67) and increase in HDL (47.25 ± 2.05) level with an increase in a dose of AAEE (41.39 ± 1.24) < (47.25 ± 2.05), which was similar to the standard drug atorvastatin. The results of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase also revealed that the plant extract was found to be safe on liver. Histopathological evaluation also revealed the positive effect of the plant extract. Preliminary phytochemical analysis revealed the presence of phytoconstituents such as saponins, glycosides and tannins. The preliminary chemical constituents stood as a strong evidence for the study. Conclusion Summing up the evidences of the pragmatic study, we can conclude that the extract of A. amara (Roxb.) Boiv. Bark aids in declining the condition of hyperlipidemia in rats.

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      Gundamaraju, R., Hwi, K. K., Singla, R. K., Vemuri, R. C., & Mulapalli, S. B. (2014). Antihyperlipidemic potential of Albizia amara (Roxb) Boiv. bark against Triton X-100 induced hyperlipidemic condition in rats. Pharmacognosy Research, 6(4), 267–273. https://doi.org/10.4103/0974-8490.138237