A Study of the Protective Effect of Triticum aestivum L. in an Experimental Animal Model of Chronic Fatigue Syndrome
Mukundam Borah1★, Phulen Sarma1, Swarnamoni Das1★ Corresponding author
- 1Department of Pharmacology, Assam Medical College, Dibrugarh, Assam, India
CORRESPONDENCE
Mukundam Borah
*Address for correspondence: Dr. Mukundam Borah, Department of Pharmacology, Assam Medical College and Hospital, Dibrugarh, Assam - 786 002, India. -
Revised: 11-03-2014.
Volume 6, Issue 4 · pp. 285–291 · PUBLISHED October-December 2014 · DOI: 10.4103/0974-8490.138251
View on Pharmacogn. Res. original site ↗
ABSTRACT
Background Oxidative stress plays a major role in the pathogenesis of chronic fatigue syndrome (CFS). Keeping in view the proven antioxidant activity of Triticum aestivum L., this study has been undertaken to explore the potential therapeutic benefit of this plant in the treatment of CFS. Objective To study the protective effect of the ethanolic extract of the leaves of Triticum aestivum (EETA) in an experimental mice model of CFS. Materials and Methods Five groups of albino mice (20-25 g) were selected for the study, with five animals in each group. Group A served as the naïve control and Group B served as the stressed control. Groups C and D received EETA (100 mg/kg and 200 mg/kg b.w.). Group E received imipramine (20 mg/kg b.w.). Except for Group A, mice in each group were forced to swim 6 min each for 7 days to induce a state of chronic fatigue. Duration of immobility was measured on every alternate day. After 7 days, various behavioral tests (mirror chamber and elevated plus maize test for anxiety, open field test for locomotor activity) and biochemical estimations (malondialdehyde [MDA] and catalase activity) in mice brain were performed. Results Forced swimming in the stressed group resulted in a significant increase in immobility period, decrease in locomotor activity and elevated anxiety level. The brain homogenate showed significantly increased MDA and decreased catalase levels. The extract-treated groups showed significantly (P < 0.05) improved locomotor activity, decreased anxiety level, elevated catalase levels and reduction of MDA. Conclusion The study confirms the protective effects of EETA in CFS.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Borah, M., Sarma, P., & Das, S. (2014). A Study of the Protective Effect of Triticum aestivum L. in an Experimental Animal Model of Chronic Fatigue Syndrome. Pharmacognosy Research, 6(4), 285–291. https://doi.org/10.4103/0974-8490.138251