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    Article

    Potential Roles of Kleinhovia hospita L. Leaf Extract in Reducing Doxorubicin Acute Hepatic, Cardiac and Renal Toxicities in Rats

    Yulia Yusrini Djabir1★, M Aryadi Arsyad2, Sartini Sartini3, Subehan Lallo4★ Corresponding author

    1. 1Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.
    2. 2Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.
    3. 3Laboratory of Microbiology, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.
    4. 4Laboratory Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.

    CORRESPONDENCE

    Yulia Yusrini Djabir

    Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.

    yuliayusrini@yahoo.com

    Volume 9, Issue 2 · pp. 168–173 · PUBLISHED 1 April 2021 · DOI: 10.4103/pr.pr_129_16

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Doxorubicin (DOX) is a potent chemotherapy agent; however, its use may lead to cardiac, hepatic, and renal dysfunction. Kleinhovia hospita L extract contains antioxidant compounds that have been shown to reduce chemical-induced hepatotoxicity. Objectives: This study aimed to examine the protective effects of Kleinhoviasp. extract to reduce DOX acute toxicities. Materials and Methods:Thirty male rats were assigned to the following groups: Group I as controls, Group II was given DOX i.p. injection (25 mg/kg); Groups III, IV, and V were treated withKleinhovia sp. extract 100, 250, and 500 mg/kg orally for 5 days, respectively, prior to DOX i.p. injection. After 24 h, blood and organs were analyzed for biomarker levels and histopathological changes. Results:DOX treatment in Group II significantly increased creatine kinase-MB (CK-MB), aspartate transaminase (AST), alanine transaminase (ALT), and urea levels compared to controls. Kleinhoviasp. extract at any given dose significantly improved ALT and AST; yet, CK-MB levels only reduced with 250 mg/kg dose (Group IV). Urea and creatinine levels in Kleinhovia sp. groups were also lower compared to DOX-treated rats, but it was not significant. Histopathological analysis showed improved liver, heart, and renal tissue structures inKleinhoviasp-treated rats, especially at higher doses. Conclusion:Kleinhovia sp. extract at any dose given protected the rats from liver toxicity, but only at dose 250 mg/kg reduced cardiac toxicity. Although renal biomarkers were insignificantly lower, renal architecture was improved with Kleinhoviasp. treatment.

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      Djabir, Y. Y., Arsyad, M. A., Sartini, S., & Lallo, S. (2021). Potential Roles of Kleinhovia hospita L. Leaf Extract in Reducing Doxorubicin Acute Hepatic, Cardiac and Renal Toxicities in Rats. Pharmacognosy Research, 9(2), 168–173. https://doi.org/10.4103/pr.pr_129_16