Volume 17, Issue 1

2026 · pp. 5–156 · 17 articles

Volume: 17
Issue: 1
Published: 2026
Pages: 5–156
Articles: 17
Sections: 4
ISSN: ISSN: Print - 0976-500X, Online - 0976-5018
Journal: J Pharmacol. Pharmacother.

Original Research Article Short Communication Case Report Review Article

In this issue

Original Research Article

Article
Curcuma xanthorrhiza Rhizome Extract Attenuates the Complete Freund’s Adjuvantinduced Rheumatoid Arthritis in Rats
Patrick A. Kalona, Uma Sundaresan, Chellappandian M., Ariharasivakumar G.
pp. 101–110 · DOI: 10.1177/0976500X251319595 · Published 2026
Background: Rheumatoid arthritis (RA) affects nearly 4% of the world’s population, along with an increasing rate of new cases. Objectives: The current work was focused on investigating the anti-arthritic efficacy of the …
Article
Comparative Study of in vitro Anti-proliferative Activity of Metformin, Teneligliptin, and Canagliflozin against Breast Cancer Cell Line
Gowri Venugopal, Kumaravelu Punnagai, Sukumar Ramya
pp. 111–116 · DOI: 10.1177/0976500X251319832 · Published 2026
Background: Cancer has become the second leading cause of death among the Indian population. Objectives: The purpose of the research was to elucidate and compare the suppressive impact on cell proliferation of metformin,…
Article
A Comparative Study of Reno-protection with Combination of N-acetylcysteine and Keto Analogs Versus Probiotics and Keto Analogs in Predialytic Chronic Kidney Disease
Zeenath Unnissa, Umair Wahedi, Zeba Fatima, Mohammed Mudassir, Parthasaradhi Sarvepally
pp. 117–126 · DOI: 10.1177/0976500X251332091 · Published 2026
Background: Chronic kidney disease (CKD) is a condition that deteriorates over time and causes the loss of nephrons, leading to impaired kidney function and finally bringing on end-stage renal disease (ESRD). As the worl…
Article
Evaluation of Topical Lifitegrast Formulations for Treatment of Psoriasis
Rahul Sudhakar Gawande, Anil Meghrajji Pethe
pp. 127–134 · DOI: 10.1177/0976500X251334168 · Published 2026
Background: Lifitegrast, a lymphocyte function-associated antigen-1 antagonist, was found to be useful in the treatment of psoriasis. Objectives: The study aimed to evaluate semisolid formulations of lifitegrast for thei…
Article
LungCTSeg-Net: Lung HRCT Image Segmentation Using Learning Approach
Vanita Dnyandev Jadhav, Lalit Vasantrao Patil
pp. 135–144 · DOI: 10.1177/0976500X251336602 · Published 2026
Background: Automatic lung segmentation is a crucial initial step in computer-aided lung computed tomography (CT) diagnosis. However, existing methods struggle to achieve accurate segmentation in the presence of dense ab…
Article
Pharmacogenomics Meets Generative AI: Transforming Clinical Trial Design with Large Language Models
Annisa Fatharani, Ali Alsayegh
pp. 17–26 · DOI: 10.1177/0976500X251321885 · Published 2026
Background: Pharmacogenomics aims to optimise drug therapy based on genetic makeup, but traditional clinical trial design faces challenges with complexity, cost and data integration. Objectives: This study explores integ…
Article
Knowledge, Attitude, and Practice on Digital Eye Strain Among Healthcare Students at a Private University in Northern Peninsular Malaysia
Lim Chin Hung, Subramani Parasuraman, Sam Aaseer Thamby
pp. 27–36 · DOI: 10.1177/0976500X251329142 · Published 2026
Background: In this modern era, the practice of online learning and various academic assignments necessitate the use of digital device among university students. With prolonged and inappropriate use, they are prone to th…
Article
Formulation and Evaluation of Bosentan Monohydrate-loaded Liposome-based Dissolving Microneedle Array Patches
Fahad Adel Balghonaim, Kumarswamy Kunigal Chandru, Madhu Bommanahalli Krishnegowda, Nimbagal Raghavendra Naveen, Prakash Goudanavar, Vedamurthy Joshi, Girish Meravanige, Predeepkumar Narayanappa Shiroorkar, Nagaraja Sreeharsha, Krishna Swaroop
pp. 37–52 · DOI: 10.1177/0976500X251327444 · Published 2026
Background: Pulmonary arterial hypertension is controlled by the dual endothelin receptor antagonist bosentan monohydrate. Recent advances in microneedle technology offer controlled, prolonged drug release. Objectives: T…
Article
Examining Medication Error Knowledge, Perceptions, and Attitudes Among Students at a Medical and Health Science University in a Cross-sectional Survey
Reem Raheem, Esha Junais, Rena Yusuf Rassal, Suresh Kumar Srinivasamurthy, Mohamedanas Mohamedfaruk Patni
pp. 53–61 · DOI: 10.1177/0976500X251336868 · Published 2026
Background: Improving patient safety is vital, with medication errors posing serious risks. Understanding health professional students’ views on errors is crucial for fostering vigilant patient safety practices among fut…
Article
Computational Screening of Bioactive Compounds of Gymnema sylvestre for ALR2 Inhibition: A Virtual Screening Approach
Khalid Alshaghdali, Raja Rezgui, Talal Alharazi, Tolgahan Acar, Gamal Mohamed Elawad Ahmed, Emad Abboh Abdallah Abboh, Kamal Yassin, Amre Nasr, Mohd Saeed, Amir Saeed
pp. 62–68 · DOI: 10.1177/0976500X251336865 · Published 2026
Background/Objectives: Complications associated with diabetes are predominantly influenced by the polyol pathway, in which aldose reductase 2 (ALR2) is instrumental in converting surplus glucose into sorbitol, resulting …
Article
Vitamin D Deficiency in Al-Madinah AlMunawwarah: A Cross-sectional Study of Prevalence Among Saudi and Non-Saudi Population
Muhammed Hassan Nasr, Noordin Othman, Bassam Abdulrasool Hassan, Mahmathi Karuppannan, Noorizan Binti Abdulaziz, Mohammed Ahmed Alsarani, Shalam Mohamed Hussain
pp. 69–76 · DOI: 10.1177/0976500X251339561 · Published 2026
Background: Vitamin D deficiency poses significant health risks globally, impacting bone health and immune function. In Saudi Arabia, where environmental and lifestyle factors limit sun exposure, vitamin D deficiency is …
Article
Combined Gene Expression Study Leads to Potential Herbal Targets in Breast Cancer and Diabetes
Sara Seifeldin, Nujud Almuzaini, Mohd Saeed, Rania Abdeen Hussain Abdalla, Md Jahoor Alam, Khalid Alshaghdali, Amir Saeed, Talal Alharazi, Elgeli Yousif
pp. 77–83 · DOI: 10.1177/0976500X251339865 · Published 2026
Background/Objectives: Diabetes and cancer are common diseases, and epidemiologic evidence suggests that people with diabetes are at significantly higher risk for many forms of cancer. Both these diseases are among the h…
Article
Comparison of Incidence of Respiratory Tract Infection in Pediatric Population Aged 1 Month to 13 Years During Pre- and PostCOVID Infection in a Tertiary Care Hospital: A Retro-prospective Observational Study
Ayisha Thacharupadikkal Thazhath, Rithwij Kakkanattu, Muhasina Razak Valatheyil, Aneena Joju, Dilip Chandrasekhar, Vipin Kalathil
pp. 84–93 · DOI: 10.1177/0976500X251321891 · Published 2026
Background: After the restoration of COVID-19 lockdowns and the relaxation of general public health restrictions, an upswing in the incidence of respiratory diseases was observed. Respiratory illnesses have been soaring …
Article
IoT Sensors in a Wireless Environment for Healthcare Monitoring: A Framework for Fault Detection
Altaf O. Mulani, Kazi Kutubuddin Sayyad Liyakat, Nilima S. Warade, Alaknanda Patil, Mahesh T. Kolte, Kishor Kinage, Manish Rana, Shweta Sadanand Salunkhe, Vaishali Satish Jadhav, Megha Nagrale
pp. 94–100 · DOI: 10.1177/0976500X251324735 · Published 2026
Background: The Internet of Things (IoT) and wireless sensor networks (WSNs) are now being explored and used in various sectors, thanks to recent technological advancements. Objectives: The healthcare sector is one of th…

Short Communication

Communication
EGFR Isoforms Might be Responsible for the Diminished Treatment Outcome of EGFR Inhibitors
Rajdeep Chakraborty, Pallavi Khodlan, Arthur Chien, Chao Shen, Thiri Zaw, Matthew Fitzhenry, Ardeshir Amirkhani, Fei Liu
pp. 145–147 · DOI: 10.1177/0976500X251321892 · Published 2026
Epidermal growth factor receptor (EGFR) plays an active role during the progression of oral squamous cell carcinoma (OSCC). OSCC is the most common head and neck cancer. Cetuximab, which is an inhibitor of EGFR, was appr…

Case Report

Article
Management of Lumbar Canal Stenosis (Katigraha) with Ayurvedic Modalities: A Case Report
Reeya Gamne, Sadhana Misar Wajpeyi, Sonia Mandal, Mayank Rai
pp. 148–156 · DOI: 10.1177/0976500X251319833 · Published 2026
Background: Lumbar canal stenosis (LCS) is a degenerative spinal condition causing narrowing of the spinal canal, leading to nerve compression. Symptoms include pain, stiffness, tingling, numbness, and difficulty walking…

Review Article

Review
Clinical Outcomes and Management of Post-varicocelectomy on Male Fertility: A Comprehensive Review
Mohammad Akbar Hossain
pp. 5–16 · DOI: 10.1177/0976500X251321295 · Published 2026
Background: Varicocelectomy is one of the main complications that, if left untreated, results in male infertility. Various approaches have been adopted to manage it, but there is a variation in the consensus. Objectives:…