Volume 17, Issue 6S

Original Article

1. Article

   Pharmacognosy and Pharmacology of Calotropis gigantea for Discovery of Anticancer Therapeutics

   Zahra Khosravi, Arun H. S. Kumar

   pp. S123–S128 · DOI: 10.4103/pm.pm_166_21 · Published 15 September 2021

   Background: Calotropis gigantea (CG) is a shrubby plant which is traditionally used for the treatment of diseases affecting the nervous system, digestive system, and skin. Several bioactive compounds from CG are isolated…

2. Article

   Evaluation of Acacia auriculiformis Benth. Leaves for Wound Healing Activity in Type 2 Diabetic Rats

   Naresh Kumar Rangra, Subir Samanta, Kishanta Kumar Pradhan

   pp. S129–S142 · DOI: 10.4103/pm.pm_496_20 · Published 15 September 2021

   Objectives: The current study is designed to decipher a shred of clinical confirmation and biochemical support for wound‑healing efficacy of methanolic leaves extract of A. auriculiformis. Materials and Methods: We prepa…

3. Article

   Ethanolic Extract of Capparis decidua Fruit Ameliorates Methotrexate‑Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation by Modulating Nuclear Factor‑Kappa B Signaling Pathway

   Preetha Santhakumar, Anitha Roy, M. Karthik Ganesh, J. Selvaraj, Lavanya Prathap, Yuvaraj Babu K

   pp. S143–S150 · DOI: 10.4103/pm.pm_402_20 · Published 15 September 2021

   Objectives: This study investigated the protective effect of C. decidua against methotrexate‑induced hepatotoxicity, focusing on its ability to attenuate oxidative stress and inflammatory nuclear factor‑kappa B (NF‑κB) s…

4. Article

   Antioxidant and Antiacetylcholinestrase Studies of In vitro Regenerated and Transformed Hairy Roots of Ocimum sanctum (L.)

   Annie Jessica Toppo, Sheela Chandra

   pp. S151–S161 · DOI: 10.4103/pm.pm_539_20 · Published 15 September 2021

   Objectives: Agrobacterium‑mediated transformation protocol has developed for O. sanctum which influences T‑DNA delivery. The antioxidant, antiacetylcholinesterase (AChE) potential, and in vivo study of hairy root extract…

5. Article

   Bioprospecting of Lobelia nicotianifolia Roth. Plant Parts for Antioxidant and Cytotoxic Activity and its Phytoconstituents

   Rupali Mukesh Kolap, Kailash D. Datkhile, Saurabha Bhimrao Zimare

   pp. S162–S171 · DOI: 10.4103/pm.pm_398_20 · Published 15 September 2021

   Objective: The objective of this study is to analyze the phytoconstituents of plant parts of L. nicotianifolia and to determine its antioxidant and cytotoxic potential. Materials and Methods: The plant parts of L. nicoti…

6. Article

   Vernonia anthelmintica (L.) Willd Extract Alleviates Cognitive Deficits and Neurodegeneration Induced by Infusion of Amyloid Beta (1–42) in Rats

   Swati Som, Justin Antony, S. Palanisamy Dhanabal, Sivasankaran Ponnusankar

   pp. S172–S179 · DOI: 10.4103/pm.pm_518_20 · Published 15 September 2021

   Objectives: The objective of the current investigation is to explore the neuroprotective activity of methanolic extract of V. anthelmintica (MEVA) in amyloid‑beta (Aβ) (1–42) infused sporadic model of AD. Materials and M…

7. Article

   Effect of Solvent Extraction System on the Antioxidant Properties of Seven Wild Edible Mushrooms and Identification of Phenolic Compounds by High‑Performance Liquid Chromatography

   Ishika Bera, Bejoysekhar Datta, Kanad Das, Tapan Seal

   pp. S180–S187 · DOI: 10.4103/pm.pm_584_20 · Published 30 July 2021

   Objectives: The main objective of this research was to analyze some selected indigenous wild mushrooms in Arunachal Pradesh, namely, Lactifluus pilosus, Lactifluus piperatus, Lactifluus indovolemus, Lactifluus crocatus, …

8. Article

   Hypoglycemic and Anti‑lipidemic Properties of Cinnamomum zeylanicum (“Sri Wijaya” Accession) Water‑soluble Nutraceutical in Streptozotocin‑induced Diabetic and Healthy Wistar Rats

   W. A. Niroshani Madushika Wariyapperuma, Bimali Jayawardena, Mayuri G. Thammitiyagodage, Ramani Karunakaran, W. G. Sarath Sisira Kumara

   pp. S188–S195 · DOI: 10.4103/pm.pm_334_20 · Published 15 September 2021

   Objectives: To investigate the hypoglycemic and antilipidemic effects of Cinnamomum zeylanicum (“Sri Wijaya” accession) water‑soluble nutraceuticals in diabetic‑induced and healthy Wistar rats. Materials and Methods: The…

9. Article

   Naringin, a Natural Flavonone Glycoside attenuates N-Nitrosodiethylamine- induced Hepatocellular Carcinoma in Sprague-Dawley rats

   Reetuparna Acharya, Namita Mishra, Abhishek Kumar, Pritha Bose, Ashok Pattnaik, Kunal Mukhopadhyay, Priyashree Sunita, Shakti Prasad Pattanayak

   pp. S196–S204 · DOI: 10.4103/pm.pm_94_21 · Published 15 September 2021

   Objectives: The present research work focuses on evaluation of chemotherapeutic efficiency, NAR against HCC in Sprague– Dawley rats. Materials and Methods: In vitro studies were primarily carried out to estimate the cell…

10. Article

    Anti‑inflammatory and Analgesic Potential of Amorphophallus commutatus var. wayanadensis and its Inhibitory Effect on Inflammatory Mediators in Lipopolysaccharide‑Stimulated Macrophages

    Sreena Raj, Rama Jayaraj, K. M. Gothandam

    pp. S205–S212 · DOI: 10.4103/pm.pm_153_21 · Published 15 September 2021

    Objectives: Hence, our study was performed to screen the anti‑inflammatory and analgesic activities of ACW. Materials and Methods: Screening for the in vitro anti‑inflammatory potential on isolated peritoneal macrophages…

11. Article

    Combinatorial Effect of Macrotyloma uniflorum (Lam.) Verdc. Seed Extract and Vorinostat (Suberoylanilide Hydroxamic Acid) in Human Leukemia Cells

    Azra Anjum, Humaira Farooqi, M.Z. Abdin, Ashok Kumar Tiwari

    pp. S213–S219 · DOI: 10.4103/pm.pm_70_21 · Published 15 September 2021

    Objectives: This study aims to evaluate the potential of Macrotyloma uniflorum in facilitating the potency of histone deacetylase inhibitor, Vorinostat‑suberoylanilide hydroxamic acid (SAHA). Materials and Methods: Powde…

12. Article

    Inhibitory Roles of Nigella sativa Seed Extracts on in vitro Glycation and Aggregation

    Umme Rubab, Dinesh Kumar, Mohammad Abul Farah, Khalid Mashay Al‑Anazi, M. Ajmal Ali, Ahmad Ali

    pp. S220–S224 · DOI: 10.4103/pm.pm_604_20 · Published 15 September 2021

    Objectives: The aim of the present study was to check the effect of Nigella sativa seed extracts on glycation and aggregation and for this purpose, two proteins (bovine serum albumin [BSA] and hemoglobin) and two sugars …

13. Article

    Effect of Salinity Stress on Growth, Water Content, and Guggulsterone Production in Callus Cultures of Commiphora wightii (Arnott.) Bhandari

    Soumi Datta, Jatin Katna, Dhiraj Shrivastav, Sarvepalli Badari Narayan, Shahid Umar, Jatavallabhula Lakshminarayana Sastry, Ranjan Mitra, Sayeed Ahmad

    pp. S225–S232 · DOI: 10.4103/pm.pm_514_20 · Published 15 September 2021

    Objectives: A traditional herb Commiphora wightii (Arnott.) is well known for the management of different ailments, including hypolipidemic and hypocholesterolemic disorders. Overexploitation has resulted in enlisting it…

14. Article

    Isolation, Characterization, and Chromatographic Estimation of Esculin: A Potential Fluorescent Marker from Launaea pinnatifida Cass

    Himanshu Makwana, Devang Pandya

    pp. S233–S239 · DOI: 10.4103/pm.pm_243_21 · Published 15 September 2021

    Objectives: The present study was performed to isolate, characterize, and estimate a potential marker compound from L. pinnatifida. Materials and Methods: The leaves of the plant were subjected to successive solvent extr…

15. Article

    Moringa oleifera Leaf Extract Exerts Antiproliferative Effects and Induces Mitochondria Mediated Apoptosis within Rat Glioblastoma (C6) Cells

    Ahmed Alafnan, Talib Hussain, Abdulwahab Alamri, Farhan Alshammari, Afrasim Moin, Syed Mohd Danish Rizvi, K. L. Krishna

    pp. S240–S245 · DOI: 10.4103/pm.pm_145_21 · Published 16 July 2021

    Objective: The present study aims to evaluate the antiproliferative efficacy of ethanolic Mo leaf extract (MoEt‑OH) in mouse‑derived glioblastoma C6 cells. Materials and Methods: MoEt‑OH was prepared, and C6 cells were s…

16. Article

    In vitro Hypoglycemic Effects of Molokhia Leaves (Corchorus olitorius L.)

    Faiyaz Ahmed

    pp. S246–S250 · DOI: 10.4103/pm.pm_525_20 · Published 15 September 2021

    Background: Corchorus olitorius L., commonly known as molokhia in Arabic, is a leafy vegetable containing large amounts of mucilaginous polysaccharides and reported to exhibit antidiabetic diabetic activity in experiment…

17. Article

    Cardioprotective Effect of Hydroalcoholic Leaf Extract of Jatropha mollissima on Isoproterenol‑induced Myocardial Infarction in Rats

    Muhammad Omer Iqbal, Imran Ahmad Khan, Ashira Manzoor, Shafia Arshad, Asad Saleem Sial, Eshwa Dar, Abdul Rashid Shaikh

    pp. S251–S256 · DOI: 10.4103/pm.pm_16_21 · Published 15 September 2021

    We aim to explore various effects of doses of Jatropha mollissima against isoproterenol‑induced myocardial infarction in the rat. Rats were divided into 6 groups (10 rats in each). Group‑1 was normal to control, and Grou…

18. Article

    Combination Effect of Spirulina fusiformis with Rutin or Chlorogenic Acid in Lipopolysaccharide‑Induced Septic Cardiac Inflammation in Experimental Diabetic Rat Model

    Aman Sharma, Sumeet Gupta, Sunil Sharma, Meenakshi Dhanawat, Kavita Munjal

    pp. S257–S267 · DOI: 10.4103/pm.pm_179_21 · Published 15 September 2021

    Background: The connection between inflammation and hyperglycemia leads to diabetes mellitus and its complications. Nutraceuticals are natural sources which can be used as supplement food for the prevention of many disor…

19. Article

    Plectranthus amboinicus (Spreng.) Semi‑purified Fractions with Selective β‑Glucuronidase Inhibition Elucidated with gas chromatography‑mass spectrometry and in silico docking

    Michael Russelle S. Alvarez, Junie Billones, Chun-Hung Lin, Francisco Heralde III

    pp. S268–S277 · DOI: 10.4103/pm.pm_149_21 · Published 15 September 2021

    Objectives: An approach to alleviating the toxic effects of these compounds is by inhibiting bacterial β‑GUS. Materials and Methods: We determined the Escherichia coli β‑GUS inhibitory activity of P. amboinicus leaves us…

20. Article

    Phenolics from the Heartwood of Tecoma mollis as Potential Inhibitors of COVID‑19 Virus Main Protease and Spike Proteins: An In silico Study

    Lamya H. Al‑Wahaibi, Md Tabish Rehman, Muneera S. M. Al‑Saleem, Omer A. Basudan, Ali A. El‑Gamal, Mohamed F. AlAjmi, Enaam Y. Backheet, Azza A. Khalifa, Wael Mostafa Abdel‑Mageed

    pp. S278–S286 · DOI: 10.4103/pm.pm_35_21 · Published 15 September 2021

    Objectives: The objective of the study is to discover the phenolic constituents of the methanolic extract of Tecoma mollis Humb. and Bonpl. heartwood and to investigate their potential inhibitory action against SARS‑CoV‑…

21. Article

    Anti-cancer Effects of Nepeta Deflersiana Extract (NDE) in Estrogen Positive and Negative Forms of Breast Cancer

    Majed Saad Al Fayi

    pp. S287–S291 · DOI: 10.4103/pm.pm_464_20 · Published 15 September 2021

    Aim: This study focused on efficacy of the ethanol extract gained from the aerial parts of Nepeta deflersiana (ND) on breast cancer (BC) cells. Materials and Methods: Shade‑dried aerial parts of ND were extracted with et…