Formulation and Evaluation of Azadirachta indica Taste Masked Oral Pellets for Gut Microbiome Modulation

ABSTRACT

Introduction Azadirachta indica has long been known for its therapeutic benefits, which include immunomodulatory and antibacterial activities. Human health is greatly influenced by the gut microbiota, and disturbances with this composition have been connected to a number of illnesses. Using natural items like Azadirachta indica to alter the gut flora provides a fresh strategy for preserving gut health and averting illness. Aim and Objectives The purpose of the present research was to create and assess Azadirachta indica taste masked oral pellets for their capacity to alter the gut microbiota and support a balanced microbial population. Materials and Methods The extrusion-spheronization technique was used to combine Azadirachta indica extract into oral pellets. An evaluation of the physicochemical properties of Azadirachta indica extract was carried out. The pellets were assessed for flow properties, loss on drying, friability, disintegration time to predict taste masking, microbial limit test and in vitro gut microbiome modulation using rat fecal samples. Results Acceptable physicochemical properties were displayed by the prepared pellets. A well-balanced formulation for quick disintegrating and effective flavor masking is shown by disintegration period, which makes oral pellets highly palatable and suitable for oral administration. Potential for gut microbiome modification was indicated by in vitro study, which showed that prepared pellets specifically suppressed harmful bacteria while encouraging the growth of healthy gut microbiota. Conclusion The Taste masked oral pellets made from Azadirachta indica demonstrated encouraging outcomes in regulating the microbes in the gut by promoting the development of beneficial bacteria. Potential applications in gut health treatments and as a prophylactic against illnesses linked to the microbiota are suggested by this.

KEYWORDS

• Azadirachta indica
• Extrusion-spheronization
• Glycyrrhiza glabra
• Taste masked oral pellets etc

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• DOI10.5530/pres.20252118Copy

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