Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    A comparative study of the effect of some nutritional medicinal plants effect on lead accumulation in the liver following different modes of administration

    Chukwuemeka Nwokocha1★, Novie Younger-Coleman2, Magdalene Nwokocha3, Daniel Owu4, Moses Iwuala5★ Corresponding author

    1. 1Department of Basic Medical Sciences
    2. 2Tropical Medicine Research Institute
    3. 3Department of Haematology, The University of The West Indies Mona Campus, Kingston Jamaica
    4. 4Department of Physiology, University of Calabar, Calabar
    5. 5Federal University of Technology, Owerri, Nigeria

    CORRESPONDENCE

    Chukwuemeka Nwokocha

    *Address for correspondence: Dr. Chukwuemeka R. Nwokocha, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Mona, Kingston 7, Jamaica.

    chukwuemeka.nwokocha@uwimona.edu.jm

    Revised: 11-03-2014.

    Volume 6, Issue 4 · pp. 306–311 · PUBLISHED October-December 2014 · DOI: 10.4103/0974-8490.138278

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Context and Objectives Lead (Pb) toxicity leads to cell damage in many organs of the body. Using different treatment interventions and modes of administration we comparatively examined the protective ability of some medicinal plants on liver Pb accumulation. Materials and Methods Rats were fed on either 7% w/w Zingiber officinale, 7% w/w Allium sativum, 10% w/w Lycopersicon esculentum, 5%, w/w Garcinia kola (all in rat chow), while Pb (100 ppm) was given in drinking water. The additives were administered together with (mode 1), a week after exposure to (mode 2) or a week before metal exposure to (mode 3) the metal for a period of 6 weeks. The metal accumulations in the liver were determined using atomic absorption spectrometry and compared using analysis of variance. Results Some additives significantly (P < 0.05) reduced, while others enhanced Pb accumulation. Mode 2 yielded the highest mean % protection and mode 3 the lowest, no significant interaction between modes of administration and time of measurement in their relationships to percentage protection, but there was statistically significant (P < 0.05) interaction between modes of administration and additive used in their relationships to percentage protection. Conclusion Protective effects of medicinal plants are varied and depend on the nature of lead exposure.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Nwokocha, C., Younger-Coleman, N., Nwokocha, M., Owu, D., & Iwuala, M. (2014). A comparative study of the effect of some nutritional medicinal plants effect on lead accumulation in the liver following different modes of administration. Pharmacognosy Research, 6(4), 306–311. https://doi.org/10.4103/0974-8490.138278