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    Evaluation of the efficacy of 2% curcumin gel in the treatment of experimental periodontitis

    Rajesh Ramesh Hosadurga1★, S. N. Rao2, Jobin Jose4, Narayana Charyulu Rompicharla4, Moidin Shakil3, R. Shashidhara5★ Corresponding author

    1. 1Departments of Periodontics
    2. 2Pharmacology and
    3. 3Oral and Maxillofacial Pathology, Yenepoya Dental College, Yenepoya University
    4. 4Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore
    5. 5Department of Oral and Maxillofacial Pathology, Coorg Institute of Dental Sciences, Maggula, Virajpet, Karnataka, India

    CORRESPONDENCE

    Rajesh Ramesh Hosadurga

    *Address for correspondence: Dr. Rajesh Ramesh Hosadurga, Department of Periodontics, Yenepoya Dental College, Yenepoya University, Mangalore - 575 018, Karnataka, India.

    drsharaj@gmail.com

    Revised: 04-06-2014.

    Volume 6, Issue 4 · pp. 326–333 · PUBLISHED October-December 2014 · DOI: 10.4103/0974-8490.138287

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Context Local drug delivery (LDD) systems have been proposed for the treatment of periodontitis. Curcumin could be a suitable agent as LDD for the treatment of periodontitis. Aim To formulate, evaluate the anti-inflammatory activity and to assess the duration of the action and the efficacy of 2% curcumin gel in the treatment of experimental periodontitis in Wistar albino rat model. Settings and Design Twenty-one Wistar albino rats were randomly assigned to three groups. Periodontitis was induced using ligature model. Group 1: Control; group 2: Plain gel, and group 3: 2% curcumin gel. Materials and Methods About 2% curcumin gel was prepared. The anti-inflammatory activity and duration of action was assessed. Silk ligature 5-0 was used to induce periodontitis. Gingival index (GI) and probing pocket depth (PPD) were measured. Treatment was done. The rats were sacrificed. Morphometric analysis was performed using stereomicroscope and ImageJ software. Statistical Analysis Used Analysis of variance followed by Bonferroni’s test, Wilcoxon’s test for inter-group comparison, Mann–Whitney test for P value computation was used. The observations are mean ± standard deviation and standard error of the mean. P < 0.01 when compared to control was considered as statistically significant. Results About 2% curcumin gel showed 42.98% inhibition of edema and peak activity was noted at 24 h. There was statistically significant change in the GI and PPD. Morphometric analysis did not show any significant difference between groups. No toxic effects were seen on oral administration of 2000 mg/kg of curcumin. Conclusions About 2% curcumin gel was effective in the treatment of experimental periodontitis.

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      Hosadurga, R. R., Rao, S. N., Jose, J., Rompicharla, N. C., Shakil, M., & Shashidhara, R. (2014). Evaluation of the efficacy of 2% curcumin gel in the treatment of experimental periodontitis. Pharmacognosy Research, 6(4), 326–333. https://doi.org/10.4103/0974-8490.138287