Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Phytochemical screening and anti-inflammatory activity of Cnidoscolus quercifolius (Euphorbiaceae) in mice

    Leandra Macedo de Araújo Gomes1, Thayne Mayra Dantas de Andrade1, Juliane Cabral Silva1, Julianeli Tolentino de Lima1, Lucindo José Quintans-Junior2, Jackson Roberto Guedes da Silva Almeida1★★ Corresponding author

    1. 1Collegiate of Pharmaceutical Sciences, Center of Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco 56.304-205
    2. 2Department of Physiology, Federal University of Sergipe, 49.100-000, São Cristóvão, Sergipe, Brazil

    CORRESPONDENCE

    Jackson Roberto Guedes da Silva Almeida

    *Address for correspondence: Prof. Jackson Roberto Guedes da Silva Almeida, Center of Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco 56.304 - 205, Brazil.

    jackson.guedes@univasf.edu.br

    Revised: 26-04-2014.

    Volume 6, Issue 4 · pp. 345–349 · PUBLISHED October-December 2014 · DOI: 10.4103/0974-8490.138290

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Cnidoscolus quercifolius is a species popularly known as “favela” and “faveleira”, and belonging to the Caatinga biome (semi-arid vegetation, Brazil), where is used in folk medicine as an anti-inflammatory. Objective The aim was to evaluate the anti-inflammatory effect of the ethanolic extract from barks (Cqb-EtOH) and leaves (Cql-EtOH) of C. quercifolius in mice using experimental models of inflammation. Materials and Methods The preliminary phytochemical analysis of the ethanolic extract was performed. The activity was evaluated by paw edema induced by carrageenan and leukocytes migration to the peritoneal cavity induced by carrageenan methods. Results A preliminary analysis of Cqb-EtOH revealed that it contained coumarins, flavonoids, monoterpenes/diterpenes and naphthoquinones, while the Cql-EtOH showed positive reaction to coumarins, anthracene derivatives, flavonoids, lignans and triterpenes/steroids. Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan. In the peritonitis test, acute pretreatment with Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited the leukocyte migration. Conclusions It can be concluded that extracts from the barks and leaves of C. quercifolius have anti-inflammatory activity, which supports the popular use of this plant to treat inflammation. Thus, extracts has significant anti-inflammatory properties, which are related probably to inhibition of release of mediators of the inflammatory process.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Gomes, L. M. D. A., Andrade, T. M. D. D., Silva, J. C., Lima, J. T. D., Quintans-Junior, L. J., & Almeida, J. R. G. D. S. (2014). Phytochemical screening and anti-inflammatory activity of Cnidoscolus quercifolius (Euphorbiaceae) in mice. Pharmacognosy Research, 6(4), 345–349. https://doi.org/10.4103/0974-8490.138290