Volume 18, Issue 2

Apr-Jun 2026 · pp. 224–631 · 40 articles

Volume: 18
Issue: 2
Published: Apr-Jun 2026
Pages: 224–631
Articles: 40
Sections: 2
ISSN: ISSN: Print - 0976-4836, Online - 0974-8490
Journal: Pharmacogn. Res.

Review Article Original Article

In this issue

Review Article

Review
Antidepressant Neuroprotective Mechanisms of Natural Products in Depression Management: A Comprehensive Review
Manjunatha Pai Chennaithody, Rajesh Kaverikana Shankar
pp. 224–236 · DOI: 10.5530/pres.20260065 · Published Apr-Jun 2026
Depression is a complex psychiatric disorder with significant global impact. While conventional antidepressants remain the mainstay of treatment, their limitations-such as delayed onset, limited efficacy, and adverse eff…
Review
Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
Megha Patel, Dilsar Gohil, Rajesh Hadia, Hemrajsingh Rajput
pp. 237–242 · DOI: 10.5530/pres.20260076 · Published Apr-Jun 2026
Colorectal Cancer (CRC) remains a pressing global health burden, with limitations in current treatments such as chemoresistance, toxicity, and tumour recurrence. Increasing interest in Phyto therapeutics has led to explo…
Review
Mining Bioactive Compounds against Drug-Resistant Microorganisms from Ethnomedicine: Examples of 32 Ethnic Medicines in Yunnan
Li-Li Chen, Min Liu, Tian-Zhen Xie, Wu-Feng Yang, Ming Gong, Yun-Xiu Cheng, Shuang Long Yang, Wei-You Xie, Zhao-Jie Wang
pp. 243–269 · DOI: 10.5530/pres.20260054 · Published Apr-Jun 2026
In the next 25 years, more than 39 million deaths worldwide could be attributed to bacterial resistance to antibiotics. Urgent action is needed to discover new antibacterial compounds. Traditional medicines worldwide hav…
Review
A Review of Integrative Plant-Based Approaches for the Management of Hashimoto Thyroiditis
Nishanthi Gunasekar, Swedha Jaganathan, Athirai Pagalavan Muthukumaravel, Buvan Raj Ayyanar, Surya Ramalingam, Hariprasath Pachaiyappan
pp. 270–278 · DOI: 10.5530/pres.20260090 · Published Apr-Jun 2026
Hashimoto Thyroiditis (HT) is one of the chronic autoimmune diseases of the thyroid gland which is characterized by the gradual destruction of the thyroid and the development of hypothyroidism. It occurs mainly in women …
Review
Unexplored Marine-Derived Microbial Metabolites as Next-Generation Antiparasitic Agents: Phytochemistry, Mechanistic Insights, and Translational Prospects
Ishita Debnath, Suman Ghosh, Nirjhar Duttagupta, Sitanshu Mondal, Jitendra Debata, Sumit Nandi, Soumik Bhattacharjee, Rana Dutta, Sajal Kumar Jha, Nabanita Banik, Mithun Bhowmik, Arindam Chatterjee, Sudip Roy, Ayantika Sil, Amites Gangopadhyay, Avijit Ghosh, Samar Patra, Shubhajit Das, Disha Das, Piyush Mahato, Bapan Khan
pp. 279–294 · DOI: 10.5530/pres.20260146 · Published Apr-Jun 2026
Background Marine-derived microbial metabolites have emerged as an underexplored but exceptionally promising source of antiparasitic agents. Over the past two decades, intensive efforts in natural product discovery have …
Review
Plant-Based Bioactive Compounds in the Prevention and Management of Liver Disorders: A Review
Shweta Bhandari, Sufiyameezan Khan, Rahul Trivedi, Rajesh Maheshwari, Swetaba Besh, Dilsar Gohil, Ujjval Vagehla
pp. 295–301 · DOI: 10.5530/pres.20260168 · Published Apr-Jun 2026
Hepatotoxicity is basically harm or else weakening of the liver functioning brought on by a variety of substances, including alcohol, medications, endotoxins, and environmental factors. Because of its high blood perfusio…
Review
Amalaki as a Natural Cardioprotective Agent: Insights from Ayurveda and Modern Medicine
Varsha Chauhan, Apoorvi Pathak, Shrikrishna Kaneriya, Dileep Kumar Awasthi Pandit, Jamwant Kumar, Srijal Soni, Kashiram Prajapati, Subnesh Kumar JAIN, Prince Sapkota, Shivam Kumar Gupta, Ganesh Jatav, Ashish Tomar
pp. 302–307 · DOI: 10.5530/pres.20260132 · Published Apr-Jun 2026
Cardiovascular Diseases (CVDs) are a leading cause of global morbidity and mortality, necessitating innovative therapeutic approaches. Traditional medicinal systems, particularly Ayurveda, emphasize natural remedies, wit…
Review
Enumeration of Botanicals of Flower, Fruit and Seed Origin Occurring in the Siddha Book Gunapadam by Murugesa Mudaliar
Brindha Sundaramoorthy, Erni Bobbili, Divya Kallingil Gopi, Sunil Kumar Koppala Narayana, Aravind Dhanush, Kanagarajan Arumugam, Narayanan Jegathambal Muthu Kumar
pp. 308–323 · DOI: 10.5530/pres.20260010 · Published Apr-Jun 2026
Background Siddha medicine, with its origin in Tamil Nadu, depicts Tamil culture and way of living. The basis of Siddha medicine is the literary works by Siddhars (physicians who practiced Siddha medicine). Such knowledg…

Original Article

Article
Anxiolytic Effects of the Pozol a Mexican Ancestral Beverage
José del Carmen Rejón-Orantes, Miguel Pérez De La Mora, Mareni Guadalupe Sánchez-Najera, Martha Julia Pascacio Pérez, Gerardo Uriel Bautista Trujillo, Minerva Crespo‐Ramírez
pp. 324–329 · DOI: 10.5530/pres.20260093 · Published Apr-Jun 2026
Background Pozol is a non-alcoholic, non-fermented pre-hispanic beverage prepared with nixtamalized maize and cocoa paste, mixed with water. This refreshing drink is nowadays yet highly consumed in some of the Mexican so…
Article
Unveiling the Anti-Inflammatory Potential of Adhatoda vasica (L) Root: An in vitro, in vivo, and in silico Correlation Study
Teasha Chakraborty, Prasenjit Mondal, Suman Acharyya, Saptarshi Samajdar, Mitali Sahoo, Soubhanik Giri, Sumanta Mondal
pp. 330–340 · DOI: 10.5530/pres.20260058 · Published Apr-Jun 2026
Objectives The present study aimed to scientifically validate the traditional use of Adhatoda vasica root for inflammation management by evaluating the anti-inflammatory activity of its aqueous (AQERAV) and Ethanolic (EE…
Article
Identification of Bioactive Phytoconstituents from the Plants as Management of Neuropathic Pain: An in silico Approach
Chintan Aundhia, Pramojeeta Rana, Jay Mukesh Chudasama, Chitrali Talele, Bhupendra Prajapati, Pranaykumar Shah, Damiki Laloo, Ghanshyam Parmar
pp. 341–352 · DOI: 10.5530/pres.20260092 · Published Apr-Jun 2026
Background Neuropathic pain affects approximately 7-8% of the global population and up to 24% in certain regions of India, posing significant challenges in management due to its complex etiology and severe symptoms. Conv…
Article
Investigations on the Anticancer Properties of Bark Extract of Couroupita guianensis against Breast Cancer
Nisha Ramesh Dubashi, Prashant Dodamani, Madan Desai, Neelam Mishra, Ramakrishna, Badarinath Druvarao Kulkarni
pp. 353–358 · DOI: 10.5530/pres.20260111 · Published Apr-Jun 2026
Background One of the major causes of death in women is breast cancer worldwide. There are a lot of shortcomings in the proper diagnosis of breast cancer at early stages in the medical field. Unremitting research is goin…
Article
Quinoxaline, a Bioactive Compound Abundant in Marine Mangroves, Attenuates Acrylamide Induced Neurotoxicity in Zebrafish via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Mechanisms
Cecileya Jasmin Meshak Dhanashekaran, Manasa Prakash, Sathyageetha Ulaganathan, Vinod Prabhu Venugopal, Radhakrishnan Narayanaswamy
pp. 359–372 · DOI: 10.5530/pres.20260129 · Published Apr-Jun 2026
Background Acrylamide, a widespread dietary and industrial contaminant, is a known neurotoxicant that promotes oxidative stress, inflammation, and neurodegeneration. Identifying effective neuroprotective agents is critic…
Article
Identification of Substitute for Traded Medicinal Plant Vamshalochana (Exudate of Bambusa arundaniaceae Wild.) Using Pharmacognostic, Phytochemical Parameters, Iron Estimation and in silico Investigation
Divya Khare, N Santhosh, V Sri Venkata Krishnan
pp. 373–385 · DOI: 10.5530/pres.20260113 · Published Apr-Jun 2026
Background Plants have been major component in medicine in all systems of medicine throughout the centuries. Though there are various plants used in different system of medicine, the availability of the original source h…
Article
Dietary Supplementation of Quercetin Delays High-Sugar Diet-Induced Premature Ovarian Aging in Drosophila melanogaster
Shilpa Mandlik, Ambre Vicky Vilas, Vaishnavi Jagtap, Radha Mhapankar, Bipinchandra Khade, Pradnya Khatav, Sharad Pawar, Deepak Kasote, Archana Sharbidre
pp. 386–395 · DOI: 10.5530/pres.20260139 · Published Apr-Jun 2026
Background High-Sugar Diets (HSD) constitute a significant lifestyle concern, contributing to metabolic disorders and accelerated aging. The fruit fly, Drosophila melanogaster, shares significant genetic and metabolic si…
Article
Comparison of Anti-Inflammatory and Antioxidant Effects of Leaves, Stem, and Seeds of Ruta chalepensis from South India
Lingaraj Jayalakshmi, Rajeshkumar Shanmugam, Sulochana Govindharaj
pp. 396–403 · DOI: 10.5530/pres.20260140 · Published Apr-Jun 2026
Background/Objectives Ruta chalepensis is a herb with many health benefits due to the abundance of secondary metabolite compounds, including both terpenoids and nonterpenoids. Comparative information on effects from indi…
Article
Green Synthesis of Zinc Oxide Nanoparticles Using Withania somnifera and Centella asiatica for Topical Herbal Skincare Applications
Nimisha Jain, Akash Nayaka, Sarah Priyanka, M Madhan
pp. 404–414 · DOI: 10.5530/pres.20260001 · Published Apr-Jun 2026
Background Growing interest in herbal-based cosmetic products has encouraged the use of environmentally friendly nanotechnology for topical skincare applications. Zinc Oxide (ZnO) nanoparticles are widely used in skin fo…
Article
Hypolipidemic and Renoprotective Effects of Methanolic Leaf Extract of Aegle marmelos in Streptozotocin-Induced Diabetic Rats: A Dose-Dependent Study
Suman Supreeti, Vartika Srivastava, Chaitali Pattanayak, Sougata Sarkar, Mangala Charan Das
pp. 415–420 · DOI: 10.5530/pres.20260143 · Published Apr-Jun 2026
Background Diabetes mellitus is a chronic metabolic disorder commonly associated with dyslipidemia and progressive renal dysfunction, contributing to long-term complications. Leaves of Aegle marmelos (Bael), a traditiona…
Article
Mineral and Heavy Metal Profiling of Different Parts of the Insulin Plant (Costus igneus) Using ICP-MS
Maharshi Bhatt, Prasanta Das
pp. 421–434 · DOI: 10.5530/pres.20260147 · Published Apr-Jun 2026
Background Medicinal plants and herb treatment have been emerging as a highly recommended method of disease management due to their therapeutic and nutritional properties. Costus igneus, the chosen plant, is commonly kno…
Article
Ethnopharmacological Evaluation of Thottea siliquosa: Phytochemical Profile, Antioxidant, and Antibacterial Activities
Pavithra Adarsha Bhat, Chandra Madaiah
pp. 435–444 · DOI: 10.5530/pres.20260124 · Published Apr-Jun 2026
Background Thottea siliquosa is an ethnomedicinal plant widely known for its antidiarrheal properties. Objectives We investigated the antibacterial and antioxidant properties of root, stem and leaves extracted using wate…
Article
Exploring the Therapeutic Potential of a Gelatin-Based Biocomposite Loaded with Moringa oleifera and Camellia sinensis: Anti-Inflammatory and Antioxidant Insights
Priyatha Prasanth, Arvina Rajasekar
pp. 445–449 · DOI: 10.5530/pres.20260156 · Published Apr-Jun 2026
Introduction Oxidative stress and chronic inflammation are central to the progression of numerous disorders. Natural bioactive compounds capable of modulating these processes are of growing interest in regenerative medic…
Article
Uncovering the Therapeutic Potential of Panchavalkala: An in silico Approach on Cervical Cancer
R S Hiremath, Rashmi Motnalli, V Sri Venkata Krishnan, Santhosh Narsimhaswamy
pp. 450–459 · DOI: 10.5530/pres.20260118 · Published Apr-Jun 2026
Background Among all cancer that affect women worldwide, cervical cancer ranks third behind colorectal and breast cancer, with 5,69,000 new cases reported each year, that requires novel therapeutic strategies in addition…
Article
Aquilaria agallocha Mitigates MPTP Induced Parkinson's Disease by Targeting the BDNF/GDNF and NRF2 Pathways: A Network Pharmacology and an in vivo Study
Preetu Shukla, Nilay Solanki, Prarambh SR Dwivedi
pp. 460–475 · DOI: 10.5530/pres.20260160 · Published Apr-Jun 2026
Background Parkinson’s Disease (PD) is a progressive neurodegenerative disorder marked by the neuronal death and a complex, multifaceted etiology. The present study aimed to investigate the potential of Aquilaria agalloc…
Article
Phytochemical Markers of Diospyros paniculata Dalzell: HPLC Validation for Juglone and Betulin with HPTLC Quantification of Juglone
Sneha Wali, Parixit Bhandurge, Nikhil Gawas, Priya Shetti
pp. 476–482 · DOI: 10.5530/pres.20260165 · Published Apr-Jun 2026
Introduction A lesser-known medicinal plant Diospyros paniculata has potential therapeutic compounds. Among these, two significant bioactive compounds are Juglone and Betulin. The pharmacological assessment of plant extr…
Article
Computational Analysis of 31 Selected Trigonella foenum-graecum (Fenugreek) Phytochemicals as Modulating Agents of Human Lutropin and Follicle Stimulating Hormone
Vijayalakshmi Thirunavukarasu, B S Sachin, Biswajit Das, Radhakrishnan Narayanaswamy
pp. 483–493 · DOI: 10.5530/pres.20260167 · Published Apr-Jun 2026
Background and Objectives Trigonella foenum-graecum (Fenugreek) has well known for various pharmacological activities. In the current investigation, we aimed to study 31 chosen phytoconstituents of T. foenum-graecum (Fen…
Article
Effect of Different Samples of Viruddha Ahara on Lactobacillus Inhibition-An Exploratory in vitro Study
Rajeshwari Vijaykumar Kamat, Rutuja Naresh Warghade, Bhumika Sundar
pp. 494–502 · DOI: 10.5530/pres.20260174 · Published Apr-Jun 2026
Background Viruddha Āhāra (incompatible food combinations) are described in Ayurveda as dietary practices that disturb digestion and metabolism, leading to doshic imbalance and disease. Though classically established, th…
Article
In silico Evaluation of Immuno-Modulatory Lead Molecules from Elephantopus scaber Linn. on Pro-Inflammatory Markers TNF-α and IL-1β
Anu Padinhapurath Abhimannue, Betty Kokkatt Poulose
pp. 503–510 · DOI: 10.5530/pres.20260171 · Published Apr-Jun 2026
Introduction Up-regulated expression of TNF-α and IL-1β is a hallmark in chronic inflammation associated pathological conditions. The World Health Organization has identified chronic inflammatory pathological conditions …
Article
Network Pharmacology and Molecular Docking Study to Reveal the Underlying Mechanism of (Arjuna) Terminalia arjuna (roxb.) Wight and arn. In the Management of Coronary Heart Disease
Praveen Nagappa Bhirdi, Suma Ramsingh Rajaput, Rohit Chandrakanth Gavali, Mandati Santhosh Reddy
pp. 511–518 · DOI: 10.5530/pres.20260172 · Published Apr-Jun 2026
Background Atherosclerosis narrows the coronary arteries, causing Coronary Artery Disease (CAD), a leading cause of morbidity and death worldwide. Conventional treatments typically focus on individual targets or pathways…
Article
Evaluation of Anti-Ulcer Activity of Ethanolic Extract of Prosopis juliflora seeds in Wistar Albino Rats
Vineeta Debbie Nesam, Arunkumar Radhakrishnan, Kawsalliya Raj, Sobita Devi
pp. 519–525 · DOI: 10.5530/pres.20262223 · Published Apr-Jun 2026
Introduction A peptic ulcer is defined as a breach in the integrity of the mucosa lining the stomach and/or duodenum that results in a localized defect or excavation due to active inflammation. Peptic ulcer disease is a …
Article
Targeting EGFR (PDB id-1XKK) for Immunomodulation: Network Pharmacology and Molecular Docking Insights into Glycyrrhiza glabra, Piper longum, and Phyllanthus emblica
Devendra Shriram Shirode, Jaydip Rajendra Bhapkar, Ashish Vilas Kulkarni, Smeeta Sudher Sadar, Jyotsna Mahesh Patil, Dhanashri Prakash Sonavane
pp. 526–537 · DOI: 10.5530/pres.20262340 · Published Apr-Jun 2026
Aim/Background Plant-derived bioactive constituents can act as immunomodulators by stimulating or suppressing immune responses. This study evaluated the immunomodulatory potential of Glycyrrhiza glabra (root), Piper long…
Article
LCMS-Based Phytochemical Screening of Albizzia lebbeck
S K Kavitha, M R Shubha, H S Yogesh, D R Bharathi, Mohammad Ali
pp. 538–547 · DOI: 10.5530/pres.20260099 · Published Apr-Jun 2026
Background and Objectives Potential antidepressant properties are shown by the ethanolic extract of Albizzia lebbeck (L.), a member of the Fabaceae family. Triterpenes, glycosides, saponins, flavonoids, and indole alkalo…
Article
Anti-Inflammatory and Analgesic Effects of Bixa orellana Chloroform Extract
Tapas Mishra, Sudhakar Kaushik, Priyanka Bisht, Bhawana Bhatt
pp. 548–554 · DOI: 10.5530/pres.20260084 · Published Apr-Jun 2026
Background Inflammation is a critical defence mechanism employed by the body in response to injury, infection, or harmful stimuli. While Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are commonly used to manage pain and …
Article
Quality Cultivation and Standardization of Withania somnifera: Comprehensive Agro-Practices and Regulatory Approach
Sanyam Sharma, Subh Naman, Ravjot Kaur, Jayesh Dwivedi, Mahendra Singh Ashawat, Arun Chandan, Nagendra Singh Chauhan, Ashish Baldi
pp. 555–567 · DOI: 10.5530/pres.20260200 · Published Apr-Jun 2026
Background The rising demand for Withania somnifera requires strict adherence to regulatory guidelines to ensure quality and efficacy. However, batch-to-batch variations, heavy metal residues, and contamination threaten …
Article
Formulation of a Bioactive Nanoemulsion of Gamma Linolenic Acid for Anti-Glioblastoma Activity
Renu Chaudhari, Farhan Jalees Ahmad, Khalid Khan, Sayeed Ahmad
pp. 568–584 · DOI: 10.5530/pres.20260182 · Published Apr-Jun 2026
Background Glioblastoma (GBM), a highly aggressive primary brain tumor, presents significant therapeutic challenges due to its inherent chemoresistance, neurotoxicity concerns, and the formidable blood-brain barrier. Gam…
Article
Medicated Kajal Ophthalmic Nanoparticulated Drug Delivery System
Kavita Nilesh Yadav, Prasad Vijay Kadam, Abhijit Sampatrao Karanje, Prachi Ashokrao Halburge, Yogesh Bapurao Kharat, Gautam Adinath Bade
pp. 585–591 · DOI: 10.5530/pres.20260122 · Published Apr-Jun 2026
Background Kajal has been used for ages as a cosmetic and to cure eye conditions in India. In order to improve therapeutic efficacy and ocular safety, we create a herbal medicated kajal with optimal extraction, formulati…
Article
Phytochemical Profiling and Bioactivity Assessment of Melaleuca bracteata F. Muell. from Nainital, Uttarakhand
Himanshu Pandey, Sushma Kholiya, Mahipal Singh, Ameeta Tiwari
pp. 592–598 · DOI: 10.5530/pres.20260159 · Published Apr-Jun 2026
Background Melaleuca bracteata (Genus: Melaleuca; Family: Myrtaceae) commonly known as the tea tree, is an important aromatic and medicinal plant. Objectives This research aims to find out the essential oil composition, …
Article
Comparative Pharmacognostic Evaluation of Terminalia arjuna (Roxb. ex DC.) Wight and Arn. and Terminalia elliptica Willd.
Arun Kumar, Debajyoti Chakraborty, Deepmala Pathak, Anil Shukla
pp. 599–608 · DOI: 10.5530/pres.20260161 · Published Apr-Jun 2026
Background Terminalia arjuna (Arjuna) and Terminalia elliptica (Asna or Saj) are two closely related medicinal tree species known for their therapeutic applications. Despite their everyday use in Ayurveda, detailed compa…
Article
GC-MS Based Phytochemical Profiling and Pharmacological Evaluation of Cynodon dactylon (Durva) Extracted in a Sesame Oil (Tila Taila) Base
Santosh Yallappa Mudakappagol, Raj Joshi, Akshaya kumar, Ujjwal Gupta
pp. 609–615 · DOI: 10.5530/pres.20260164 · Published Apr-Jun 2026
Background Durva Taila is a classical Ayurvedic formulation prepared by processing the fresh juice of Durva (Cynodon dactylon) in Tila Taila (Sesamum indicum oil). It has long been utilized to treat inflammatory diseases…
Article
Antioxidant, Antimicrobial and Antiproliferative Effects of Serjania racemosa Schumach Leaves
Oscar Antonio Sánchez-Aguirre, Daniel Salazar-Vela, Marina Guevara-Valencia, Enrique Juárez-Aguilar, Omar Germán Malagón-Avilés, Leticia Margarita Cano-Asseleih
pp. 616–624 · DOI: 10.5530/pres.20260133 · Published Apr-Jun 2026
Background Serjania racemosa Schumach, popularly known in Mexico as bejuco siete corazones (seven-hearted bejuco), is used in traditional medicine for the treatment of a wide variety of conditions, including urinary and …
Article
Phytochemical, Antimicrobial, and Anti-inflammatory Studies of Zingiber neesanum (Graham) Ramam
Therese Jose, Renji Varghese, Jinu John, Rogimon Plammoottil Thomas
pp. 625–631 · DOI: 10.5530/pres.20260105 · Published Jul-Sep 2026
Background Zingiber neesanum, which belongs to the Zingiberaceae family, was the subject of the current investigation. Besides being a significant medicinal plant species, it is an aromatic stimulant. Objectives Examinin…